Lambrolizumab induced central nervous system (CNS) toxicity
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چکیده
منابع مشابه
HYPERVITAMINOSIS A-INDUCED CENTRAL NERVOUS SYSTEM DEFECTS
In this investigation the effects of excess vitamin A administration during the early embryonic period were studied. Intramuscular injection of a single dose of 15000,20000 or 25000 IU/kg vitamin A to pregnant Balb/c strain mice on either day 7,8,9 or 10 of gestation (vaginal plug= day 0 of gestation) produced major malformations in the central nervous system (CNS) including exencephaly, h...
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The semisynthetic derivative of camptothecin, irinotecan (CPT-11), has been used extensively as second-line chemotherapy for metastatic colorectal carcinoma resistant to 5-fluorouracil (5FU) and has also been studied in other tumor types (1–3). The toxic effects of irinotecan mainly consist of neutropenia, diarrhea, and cholinergic-like syndrome. Other toxic effects include alopecia, nausea and...
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Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand Department of Chemistry, Center of Membrane Sciences, and Sanders-Brown Center on Aging, 121 Chemistry-Physics Building, University of Kentucky, Lexington, KY 40506, USA Department of Physiology, University of Kentucky, Lexington, KY 40536, USA D...
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The clinical effectiveness of adriamycin (ADR), a potent chemotherapeutic, is known to be limited by severe cardiotoxic side effects. However, the effect of ADR on brain tissue is not well understood. It is generally thought that ADR is not toxic to the brain because ADR does not pass the blood-brain barrier. The present study demonstrates that ADR autofluorescence was detected only in areas of...
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OBJECTIVE To assess patient and medication factors that contribute to metronidazole toxicity. DATA SOURCES We searched PUBMED from 1965 through April 7, 2011, and performed a hand search of bibliographies. STUDY SELECTION Case reports or case series reporting metronidazole-induced central nervous toxicity. DATA EXTRACTION Two authors independently abstracted demographics, metronidazole in...
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ژورنال
عنوان ژورنال: Journal of the Neurological Sciences
سال: 2014
ISSN: 0022-510X
DOI: 10.1016/j.jns.2014.06.023